Cardiff University, Cardiff Programs, Tuition Fees & Entry Requirements 2022-2023

Doctor of Philosophy [Ph.D] [KESS2 PhD in Biosciences: Delineating how oncogenic PI3K/PTEN signalling contributes to prostate cancer] From Cardiff University

Cardiff, WalesLocation
UniversitySchool type
Estd1883established year
24245enrollment
Public
8.1/10

Doctor of Philosophy [Ph.D] (KESS2 PhD in Biosciences: Delineating how oncogenic PI3K/PTEN signalling contributes to prostate cancer)

3 years
Full Time

Field of Study

  • Despite high response rates to androgen deprivation therapy (ADT) in advanced PCa patients, nearly all eventually develop progressive, castrate-resistant prostate cancer (CRPC). The mainstay of treatment for lethal CRPC is chemotherapy/ADT, yet survival is poor, emphasising the urgent clinical need to identify novel therapeutic strategies to treat PCa/CRPC.
  • Owing to the high frequency of oncogenic PI3K signalling in PCa/CRPC and its link to ADT resistance, this pathway is an attractive therapeutic target. Indeed loss of PTEN, a negative regulator of the PI3K pathway, occurs in 50-70% of PCa patients and is an inherent property of CRPC in mice.
  • Nevertheless, how the PI3K pathway contributes to PCa growth and CRPC transition is not clear. Dr. Pearson has recently discovered that hyperactivation of the PI3K catalytic subunit p110a (encoded by PIK3CA) causes rapid de novo castration resistance in combination with Pten loss, yet single mutants acquire CRPC over time.

Important Dates

University allocates places on a first-come, first-served basis, so students are recommended to apply as early as possible.

Scholarship Grants & Financial Aids

NameScholarship Per StudentLevel of StudyType
Robert S. McNamara Fellowship ProgramScholarship per student₹ 26.2 L/Yr$25,000Level Of StudyDoctorateTypeMerit-Based
Paul Foundation scholarshipsScholarship per student₹ 21.2 L/Yr$20,174Level Of StudyDiplomaTypeMerit-Based
Debesh Kamal ScholarshipScholarship per student₹ 1.5 L/Yr$1,385Level Of StudyBachelorTypeMerit-Based
Ms. Agatha Harrison Memorial FellowshipScholarship per student₹ 34.7 L/Yr$33,115Level Of StudyDoctorateTypeCollege-Specific
BrokerFish International student scholarshipScholarship per student₹ 1 L/Yr$1,000Level Of StudyBachelorTypeMerit-Based
QS scholarshipsScholarship per studentVariable AmountLevel Of StudyBachelorTypeMerit-Based


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